Skip to main content
  • Research article
  • Open access
  • Published:

The effectiveness of vibrational stimulus to accelerate orthodontic tooth movement: a systematic review



In recent years, it has been a hot research topic to accelerate orthodontic tooth movement (OTM) through vibration. This review was therefore aimed to systematically evaluate the available evidences on the efficacy of vibrational stimulus to accelerate OTM.


Randomized controlled trials and controlled clinical trials that evaluated the efficacy of vibration on OTM acceleration were searched through electronic and manual search. Two review authors independently conducted the study inclusion, quality assessment and data extraction. The quality of synthesized evidence was assessed according to GRADE system.


Eight clinical trials were included in this systematic review. Four studies found that vibration did not enhance the rate of OTM during alignment phase. Two studies revealed that the use of vibratory stimulation accelerated canine retraction. No deleterious effects including pain perceptions and root resorptions were reported.


Within the limitations of this review, weak evidence indicates that vibrational stimulus is effective for accelerating canine retraction but not for alignment. The effects of vibration on pain intensity and root resorption during orthodontic treatment are inconclusive. Future high-quality clinical trials are needed before warranting recommendations to clinical application.

Peer Review reports


The length of orthodontic treatment, which normally ranges from 24 to 36 months, is one of the main concerns to patients [1, 2]. The prolonged treatment duration could reduce the compliance of patients, and cause numerous adverse effects including white spot lesions, periodontal diseases and external root resorptions [3, 4]. Therefore, approaches to speed up orthodontic tooth movement (OTM) and the resulting reduction of treatment duration are always desirable to orthodontists and patients.

In recent years, numerous surgical and nonsurgical adjunctive procedures to accelerate OTM have been introduced [5,6,7]. Surgical techniques like corticotomy have been reported to facilitate tooth movement in short term via inducing regional acceleratory phenomenon [5, 7]. However, the invasiveness and postoperative discomfort make patients less receptive to these techniques and restrict the routine application in clinics [8]. Several nonsurgical adjuncts including laser therapy, electric current, pulsed electromagnetic fields and photobiomodulation are suggested to promote tooth movement [9,10,11]. However, the use of these approaches is also limited since the necessity of performance by disciplined clinicians and low quality of evidence [5, 9].

Among the nonsurgical interventions, vibrational stimulus is promising and has already been commercial since portability, convenience and invasiveness. The potency of applying vibrational stimulus to accelerate OTM has been identified in previous animal studies [12, 13]. Recently, several clinical reports have investigated the effects of vibrations on the rate of tooth movement [14,15,16,17,18,19,20,21,22,23]. Nevertheless, the methodological heterogeneity and inconclusive results of these studies could cause difficulties to evaluate evidences and mislead clinical practice. Therefore, a comprehensive systematic review addressing the effectiveness of vibration to accelerate OTM would be beneficial to practitioners.

In this study, we performed a critical systematic review on randomized controlled trials (RCT) and controlled clinical trials (CCT) to evaluate the efficacy of vibration in accelerating tooth movement in an evidence-based approach.


This systematic review was carried out and reported according to Cochrane Handbook for Systematic reviews of Interventions [24] and Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) [25]. Two review authors performed the literature search, study inclusion, data extraction and risk of bias assessment independently. Any discrepancy was resolved by reaching a consensus through discussion with a third reviewer.

Eligibility criteria

The inclusion criteria were as follows: (1) The study should evaluate the effectiveness of vibrational stimulus on OTM; (2) Study design: the study should be RCT or CCT; (3) Participants: subjects should be systematically healthy patients who require orthodontic treatment; (4) Type of interventions: subjects should be assigned to experimental or control/placebo group based on receiving vibrational stimulus or not; (5) Type of outcomes: indicator of tooth movement velocity and related treatment parameters.

The exclusion criteria were as follows: (1) Retrospective design, cohort study, case reports, descriptive studies or letters; (2) Animal experiments; (3) Participants with systematic diseases that affect bone metabolism or orthodontic treatment.

Information sources, search strategy, and study selection

PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and System for Information on Grey Literature in Europe (SIGLE) were searched for literature until Nov 2016. We adopted a combination of Medical Subject Headings (MeSH) with related free text words for the search in PubMed, and optimized the search strategy for each database respectively. The specific search strategies were presented in Table 1. In addition, a manual search was conducted among relevant journals and reference sections of retrieved records. The search was carried out in English without publication time limitation.

Table 1 Search strategies for Each Database

After the removal of duplicate records, the titles and abstracts of identified studies were screened to exclude irrelevant citations. The full-text of reserved studies were retrieved and assessed referring to eligibility criteria by two reviewers independently.

Data items and collection

A customized form was developed for data extraction. The general information of recruited studies including author, publication year, country, demographic information, vibration parameters, type of tooth movement, follow-ups and results were extracted.

The primary outcome of interest in this review was the rate of tooth movement, time needed to complete a predefined tooth movement and accumulated moved distance. The secondary outcome included patients’ quality of life and adverse effects like root resorption and discomfort.

Risk of bias in individual studies

The risk of bias of included trials were evaluated according to Cochrane Collaboration’s tool for assessing risk of bias [26]. This tool assesses the methodological quality of clinical trials through seven domains including random sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, incomplete outcome, selective reporting and other bias. The primary study was categorized as low risk when all items being assessed as low risk of bias, as unclear risk if one of more items being assessed as unclear risk of bias, and as high risk when one or more items being assessed as high risk of bias [26].

Summary measures and approach to synthesis

The original outcome data regarding the efficacy of vibration were extracted and had been planned to undergo statistical pooling when the heterogeneity of primary studies was acceptable. When conducting meta-analysis failed, a qualitative summarization of evidences was adopted. The quality of synthesized evidence was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE) system [27].


Study selection and characteristics

The details of search results are depicted in a PRISMA flow-diagram (Fig. 1). Three hundred fourteen studies were identified in the electronic databases, and two additional records were found through manual search. After removal of the duplicates, a total of 269 citations were screened based on title and abstract. Subsequently, full texts of the 14 reserved studies were retrieved for assessment referring to the inclusion and exclusion criteria. Finally, eight studies were included in the review [16,17,18,19,20,21,22,23]. The Cohen’s-Kappa coefficient was used to measure inter-examiner agreement in the study selection process [24]. The kappa score was 0.86, indicating the interrater bias was low [28].

Fig. 1
figure 1

PRISMA flow diagram of study selection

The general information of included studies was presented in Table 2. Out of the eight studies, seven were RCTs [16,17,18,19, 21,22,23] and one was demarcated as CCT [20]. Three publications were different parts of a same clinical trial, and were all included in this review since each of them reported an important outcome of vibration-assisted orthodontics respectively (tooth movement velocity, pain and discomfort, and root resorption) [17,18,19]. The sample size of single primary study ranged from 15 to 81. A total of 305 participants were involved in present review, among which 149 subjects underwent vibrational stimulus and 171 patients were assigned into sham/control group (15 patients were involved in split-mouth design). The priori sample size calculation was conducted in seven studies [16,17,18,19, 21,22,23].

Table 2 Overview of included studies

Risk of bias within studies

The results of risk of bias assessment are summarized in Fig. 2. Among the eight studies, two studies (from a same clinical trial) were assessed as low risk of bias [17, 18], four were rated as unclear risk of bias [16, 19, 21, 22], and two were high risk of bias [20, 23]. Sixed studies adequately addressed random sequence generation [17,18,19, 21,22,23], and five of them were considered as reliable in allocation concealment [17,18,19, 21, 22]. The items regarding randomization and allocation concealment in CCT were set by default as high risk [20]. Since the use of vibrational devices, participants could not be blinded, which might influence the visual analogue scale scoring for pain perceptions. Therefore four studies were assessed as unclear risk for performance bias [16, 21,22,23]. Woodhouse et al. included a group of subjects using sham appliance and adequately considered the blind for participants regarding the allocation of functional and sham group [17]. Thus it was assessed as being free of performance bias [17]. Two studies did not report the details of missing data of drop-outs, thus were considered as unclear risk for attrition bias [16, 21]. High risk of other bias was present in two studies since split-mouth design and sponsorship from manufacturer of vibrational devices respectively [20, 23]. Unclear risk of other bias was detected in one study since root resorptions were evaluated using periapical radiographs [19].

Fig. 2
figure 2

Risk of bias summary for included studies

Description of interventions

All the included studies investigated the effects of vibrational stimulus on orthodontic treatment, but the procedures of vibrational stimulus and tooth movement differed (Tables 2, 3). One study adopted Tooth Masseuse that provided a vibrational force of 111 Hz and 0.06 N for 20 min per day [16]. Six studies used AcceleDent (OrthoAccel Technologies, Inc., Bellaire, TX) which delivers a vibrational force of 0.25 N with a frequency of 30 Hz [17,18,19, 21,22,23]. The other one study employed an electrical toothbrush with a vibration head (125 Hz) [20]. When concerning the type of tooth movement, six studies investigated mandibular teeth alignment [16,17,18,19, 21, 22] and the other two focused on maxillary canine retraction (Table 2) [20, 23].

Table 3 Characteristic of interventions and results

Results of individual studies and data synthesis

Since the substantial differences in vibration parameters, type of tooth movement and outcome measurements among included studies (Tables 2, 3), it is difficult to quantitatively combine the original outcome. Thus, the results of included trials were summarized qualitatively. The quality of synthesized evidence for each outcome was assessed using GRADE approach and presented in Table 4.

Table 4 GRADE assessment for quality of evidence

Rate of tooth movement in alignment

Miles et al. compared the reduction of irregularity index of mandibular anterior teeth between patients receiving vibrational stimulus (Tooth Masseuse) or not. No significant difference of mean irregularity index reduction between two groups was detected at 5 (50% vs 45%), 8 (61% vs 61%) or 10 weeks (65% vs 69%) after commencement [16]. Thereafter, Miles et al. investigated the effectiveness of AcceleDent device in another trial, and observed similar rates of anterior lower teeth alignment between experimental and control groups [22]. Woodhouse and DiBiase et al. conducted a RCT involving patients treated with AcceleDent vibrational device, nonfunctional device or orthodontic treatment only, and reported results of alignment rate in two publications. One study showed that the time required for initial and final alignment of mandibular dentition were similar among three groups (initial alignment: 56.3 vs 59.8 vs 61.0 day; final alignment: 210.2 vs 217.5 vs 200.7 day) [18]. Similarly, the other study demonstrated no difference in the average rate of initial alignment was observed (0.10 ± 0.05 mm vs 0.11 ± 0.06 mm vs 0.10 ± 0.05 mm) [17]. These two publications were considered as one study for constructing body evidence (Table 4). According to GRADE, the quality of evidence on the effect of vibrations on alignment is assessed as very low (Table 4).

Rate of tooth movement in canine distalization

Pavlin et al. [23] reported the average rate of maxillary canine retraction was significantly enhanced by using AcceleDent device for 20 min per day (1.16, 95% CI: 0.86–1.45 mm/month vs 0.79, 95%CI: 0.49–1.09 mm/month). Leethanakul et al. [20] showed the accumulative distance of canine distalization on the quadrant receiving stimulation from a vibrating head (125 Hz) of electronic toothbrush was enhanced compared to the control side (2.85 ± 0.17 mm vs 1.77 ± 0.11 mm). The quality of evidence supporting the efficacy of vibrations on canine retraction is assessed as very low (Table 4).

Pain and discomfort

Five studies evaluated the effects of vibrational stimulus on pain intensities using visual analogue scale (VAS). Miles et al. found the use of vibratory device (Tooth Masseuse) did not reduce pain perceptions at 6-8 h (39.6 ± 25.8 mm vs 40.4 ± 20.8), 1 day (47.6 ± 24.5 mm vs 41.5 ± 27.2), 3 days (19.9 ± 15.5 mm vs 18.8 ± 18.5) and 7 days (5.5 ± 7.8 mm vs 4.0 ± 6.3) after placing appliances [16]. Similar results were observed in another RCT conducted by Miles et al., which adopted AcceleDent to produce vibrational stimulus [22]. Woodhouse et al. found either the maximum or mean pain intensities in the first week after placement of 0.014-in. and 0.018-in. NiTi archwires were similar among the vibration (AcceleDent), sham (nonfunctional AcceleDent) and control group [17]. Pavlin et al. also reported that no significant difference in pain or discomfort was detected in participants treated with vibrations or not. On contrary to the foregoing studies which suggested that vibrational stimulus did not influence pain levels, Lobre et al. evaluated the biting and overall pain in the first 4 month of treatment, and found that patients treated with vibration (AcceleDent) perceived both biting (P = 0.003) and overall pains (P = 0.002) of lower intensities during the whole study period [21].

Root resorption

DiBiase et al. evaluated the right maxillary central incisor lengths before and after alignment using periapical radiographs, and found the orthodontically induced inflammatory root resorption was not affected by application of supplemental vibrational force [17]. Similarly, Pavlin et al. reported no difference in root resorption after canine retraction between patients using vibrational device (AcceleDent) or not [23].


To our knowledge, this is the first systematic review addressing the efficacy of vibrational stimulus to accelerate OTM. This review included eight prospective clinical trials comprising an overall sample of 305 patients. The heterogeneity in methodology and non-comparability of outcome measures in retrieved publications prevented a quantitative synthesis from being performed. Therefore, we collected, appraised and qualitatively synthesized the currently available literatures to provide evidence regarding this issue.

Four studies [16,17,18, 22] in this review investigated the rate of tooth movement in alignment, two of which were the different parts of a same RCT [17, 18]. All of the four publications reported that the use of vibratory device could not enhance the velocity of tooth movement during alignment (Table 3). However, this result should be interpreted with caution since following reasons. Firstly, only four publications (three clinical trials) are included for this outcome, and the methodological flaws are noteworthy (Fig. 2). Secondly, vibrational stimuli are different in the four studies (Tables 2, 3). Thirdly, Studies reported by Miles et al. [16, 22] focused on the alignment of lower anterior teeth in patients without extraction in mandible while the other two studies reported by Woodhouse et al. [17, 18] aligned the whole mandibular dentition in patients that had mandibular first premolars extracted (Table 3). Due to the reasons above, quality of this evidence was assessed as very low quality referring to GRADE guidance (Table 4) [27].

Two studies [20, 23] evaluated the effects of vibration on canine distalization in patients that had maxillary first premolar extracted (Tables 2, 3). Results of the two studies advocated the advantage of vibrational forces in acclerating canine retraction (Table 3). Leethanakul et al. detected enhanced IL-1β secretion in gingival crevicular fluid in quadrant receiving vibrational stimulus compared to the control quadrant [20]. IL-1 could induce RANKL expression in osteoblasts and periodontal ligament cells, and also promote the differentiation of pre-osteoclast [29]. Interestingly, a well-designed animal study indicated that vibration could promote osteoclast formation via enhancing RANKL expression in periodontal tissue and thus facilitate alveolar bone remodeling and lead to faster tooth movement [13]. These studies suggested that vibrational stimulus could accelerate OTM through promoting osteoclast formation and alveolar bone remodeling. However, current evidence supporting the effectiveness of vibration on accelerating canine distalization is of very low quality, mainly due to the lack of high-quality primary studies and methodological heterogeneity (Table 4).

Vibratory stimulations have been proved to reduce pain perceptions in different fields [30, 31]. Five studies in this review investigated effects of vibrations on orthodontic pain (Table 3). However, the reliability of these results is questionable since the absence of blinding to participants could influence the VAS scoring for pain levels. Only one study was free of this bias since it included participants intervened with identical non-functional device and concealed the allocation of functional and non-functional group, which suggested that vibration did not influence pain levels [17]. Anyway, no conclusion concerning the effects of vibration on pain and discomfort could be drawn based on current information.

Root resorption is one of the main complications in orthodontic treatment [32]. DeBiase et al. assessed the changes of root lengths after orthodontic treatment using periapical radiographs [19]. However, film radiographs could only provide information of apical root resorptions. The resorptions occurring at other sites on root could be underestimated [33]. Another study observed no impact of vibrations on root resorptions. Nevertheless, no details of measurements and outcomes were reported [23]. In general, no reliable result on root resorption is available yet.

OTM is the consequence of tissue remodeling within periodontium induced by external forces [34]. Most of the current adjunctive interventions, like corticotomy, enhance the rate of tooth movement by promoting alveolar bone remodeling [35]. The anabolic effects of supplemental vibrational therapy on bone metabolism have been long recognized [36]. Its effectiveness in promoting suture growth and remodeling in craniofacial region has also been identified [37]. A recent study indicates that vibration could accelerate OTM through promoting alveolar bone remodeling [13]. However, another experiment found that mechanical vibration did not increase the number of osteoclasts or rate of tooth movement [38]. It should be noted that distinguished difference of vibration frequency exists in these two animal studies (60 vs 5–20 Hz), indicating that vibratory stimulus could act in a frequency-dependent manner. Therefore, future clinical trials should be carried out to explore the optimal protocols of vibratory forces for accelerating OTM.

Although this systematic review was performed carefully following normalized procedures, several limitations which deserved further discussion still existed. First, the shortage of high-quality clinical trials is evident. Though a comprehensive literature search was performed, only eight studies were included in this review. Future well-designed studies are needed to obtain a more reliable conclusion. Second, the methodological heterogeneity and non-comparability of original outcomes could bias the qualitative summarization of this review. Third, the publication bias has not been investigated since the weak statistical power when included publications are limited [39]. Fourth, the language restriction in literature search could have introduced bias into this review.


Based on current information, weak evidence suggests that vibrational stimulus is effective for accelerating tooth movement in canine retraction but not in the alignment phase. The effects of vibration on pain intensity and root resorption during orthodontic treatment are inconclusive. There is a need for well-designed randomized controlled trials to obtain more reliable results.



Controlled clinical trials


Cochrane Central Register of Controlled Trials


Grading of Recommendations Assessment, Development and Evaluation


Medical Subject Headings


Orthodontic tooth movement


Preferred Reporting Items for Systematic Reviews and Meta-analyses


Randomized controlled trials


System for Information on Grey Literature in Europe


Visual analogue scale


  1. Fisher MA, Wenger RM, Hans MG. Pretreatment characteristics associated with orthodontic treatment duration. Am J Orthod Dentofac Orthop. 2010;137:178–86.

    Article  Google Scholar 

  2. Mavreas D, Athanasiou AE. Factors affecting the duration of orthodontic treatment: a systematic review. Eur J Orthod. 2008;30:386–95.

    Article  PubMed  Google Scholar 

  3. Geiger AM, Gorelick L, Gwinnett AJ, Benson BJ. Reducing white spot lesions in orthodontic populations with fluoride rinsing. Am J Orthod Dentofac Orthop. 1992;101:403–7.

    Article  Google Scholar 

  4. Pandis N, Nasika M, Polychronopoulou A, Eliades T. External apical root resorption in patients treated with conventional and self-ligating brackets. Am J Orthod Dentofac Orthop. 2008;134:646–51.

    Article  Google Scholar 

  5. Gkantidis N, Mistakidis I, Kouskoura T, Pandis N. Effectiveness of non-conventional methods for accelerated orthodontic tooth movement: a systematic review and meta-analysis. J Dent. 2014;42:1300–19.

    Article  PubMed  Google Scholar 

  6. El-Angbawi A, McIntyre GT, Fleming PS, Bearn DR. Non-surgical adjunctive interventions for accelerating tooth movement in patients undergoing fixed orthodontic treatment. Cochrane Database Syst Rev. 2015;18:Cd010887.

    Google Scholar 

  7. Fleming PS, Fedorowicz Z, Johal A, El-Angbawi A, Pandis N. Surgical adjunctive procedures for accelerating orthodontic treatment. Cochrane Database Syst Rev. 2015;30:Cd010572.

    Google Scholar 

  8. Zawawi KH. Patients' acceptance of corticotomy-assisted orthodontics. Patient Prefer Adherence. 2015;9:1153–8.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Kalemaj Z, Debernard IC, Buti J. Efficacy of surgical and non-surgical interventions on accelerating orthodontic tooth movement: a systematic review. Eur J Oral Implantol. 2015;8:9–24.

    PubMed  Google Scholar 

  10. Showkatbakhsh R, Jamilian A, Showkatbakhsh M. The effect of pulsed electromagnetic fields on the acceleration of tooth movement. World J Orthod. 2010;11:e52–6.

    PubMed  Google Scholar 

  11. Kau CH, Kantarci A, Shaughnessy T, Vachiramon A, Santiwong P, de la Fuente A, Skrenes D, Ma D, Brawn P. Photobiomodulation accelerates orthodontic alignment in the early phase of treatment. Prog Orthod. 2013;14:30.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Darendeliler MA, Zea A, Shen G, Zoellner H. Effects of pulsed electromagnetic field vibration on tooth movement induced by magnetic and mechanical forces: a preliminary study. Aust Dent J. 2007;52:282–7.

    Article  PubMed  Google Scholar 

  13. Nishimura M, Chiba M, Ohashi T, Sato M, Shimizu Y, Igarashi K, Mitani H. Periodontal tissue activation by vibration: intermittent stimulation by resonance vibration accelerates experimental tooth movement in rats. Am J Orthod Dentofac Orthop. 2008;133:572–83.

    Article  Google Scholar 

  14. Bowman SJ. The effect of vibration on the rate of leveling and alignment. J Clin Orthod. 2014;48:678–88.

    PubMed  Google Scholar 

  15. Orton-Gibbs S, Kim NY. Clinical experience with the use of pulsatile forces to accelerate treatment. J Clin Orthod. 2015;49:557–73.

    PubMed  Google Scholar 

  16. Miles P, Smith H, Weyant R, Rinchuse DJ. The effects of a vibrational appliance on tooth movement and patient discomfort: a prospective randomised clinical trial. Aust Orthod J. 2012;28:213–8.

    PubMed  Google Scholar 

  17. Woodhouse NR, DiBiase AT, Papageorgiou SN, Johnson N, Slipper C, Grant J, Alsaleh M, Cobourne MT. Supplemental vibrational force does not reduce pain experience during initial alignment with fixed orthodontic appliances: a multicenter randomized clinical trial. Sci Rep. 2015;5:17224.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Woodhouse NR, DiBiase AT, Johnson N, Slipper C, Grant J, Alsaleh M, Donaldson AN, Cobourne MT. Supplemental vibrational force during orthodontic alignment: a randomized trial. J Dent Res. 2015;94:682–9.

    Article  PubMed  Google Scholar 

  19. DiBiase AT, Woodhouse NR, Papageorgiou SN, Johnson N, Slipper C, Grant J, Alsaleh M, Cobourne MT. Effect of supplemental vibrational force on orthodontically induced inflammatory root resorption: a multicenter randomized clinical trial. Am J Orthod Dentofac Orthop. 2016;150:918–27.

    Article  Google Scholar 

  20. Leethanakul C, Suamphan S, Jitpukdeebodintra S, Thongudomporn U, Charoemratrote C. Vibratory stimulation increases interleukin-1 beta secretion during orthodontic tooth movement. Angle Orthod. 2016;86:74–80.

    Article  PubMed  Google Scholar 

  21. Lobre WD, Callegari BJ, Gardner G, Marsh CM, Bush AC, Dunn WJ. Pain control in orthodontics using a micropulse vibration device: a randomized clinical trial. Angle Orthod. 2016;86:625–30.

    Article  PubMed  Google Scholar 

  22. Miles P, Fisher E. Assessment of the changes in arch perimeter and irregularity in the mandibular arch during initial alignment with the AcceleDent Aura appliance vs no appliance in adolescents: a single-blind randomized clinical trial. Am J Orthod Dentofac Orthop. 2016;150:928–36.

    Article  Google Scholar 

  23. Pavlin D, Anthony R, Raj V, PT G. Cyclic loading (vibration) accelerates tooth movement in orthodontic patients: a double-blind, randomized controlled trial. Semin Orthod. 2015;21:187–94.

    Article  Google Scholar 

  24. Higgins J, Green S. Cochrane handbook for systematic reviews of interventions. Chichester: Wiley; 2009.

    Google Scholar 

  25. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JA, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schunemann HJ, Group GW. GRADE an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336:924–6.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–74.

    Article  PubMed  Google Scholar 

  29. Teixeira CC, Khoo E, Tran J, Chartres I, Liu Y, Thant LM, Khabensky I, Gart LP, Cisneros G, Alikhani M. Cytokine expression and accelerated tooth movement. J Dent Res. 2010;89:1135–41.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Lundeberg T, Nordemar R, Ottoson D. Pain alleviation by vibratory stimulation. Pain. 1984;20:25–44.

    Article  PubMed  Google Scholar 

  31. Roy EA, Hollins M, Maixner W. Reduction of TMD pain by high-frequency vibration: a spatial and temporal analysis. Pain. 2003;101:267–74.

    Article  PubMed  Google Scholar 

  32. Weltman B, Vig KW, Fields HW, Shanker S, Kaizar EE. Root resorption associated with orthodontic tooth movement: a systematic review. Am J Orthod Dentofac Orthop. 2010;137:462–76.

    Article  Google Scholar 

  33. Yi J, Sun Y, Li Y, Li C, Li X, Zhao Z. Cone-beam computed tomography versus periapical radiograph for diagnosing external root resorption: a systematic review and meta-analysis. Angle Orthod. 2016;87:328–37.

    Article  PubMed  Google Scholar 

  34. Wise GE, King GJ. Mechanisms of tooth eruption and orthodontic tooth movement. J Dent Res. 2008;87:414–34.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Alikhani M, Raptis M, Zoldan B, Sangsuwon C, Lee YB, Alyami B, Corpodian C, Barrera LM, Alansari S, Khoo E, et al. Effect of micro-osteoperforations on the rate of tooth movement. Am J Orthod Dentofac Orthop. 2013;144:639–48.

    Article  Google Scholar 

  36. Rubin C, Turner AS, Muller R, Mittra E, McLeod K, Lin W, Qin YX. Quantity and quality of trabecular bone in the femur are enhanced by a strongly anabolic, noninvasive mechanical intervention. J Bone Miner Res. 2002;17:349–57.

    Article  PubMed  Google Scholar 

  37. Peptan AI, Lopez A, Kopher RA, Mao JJ. Responses of intramembranous bone and sutures upon in vivo cyclic tensile and compressive loading. Bone. 2008;42:432–8.

    Article  PubMed  Google Scholar 

  38. Yadav S, Dobie T, Assefnia A, Gupta H, Kalajzic Z, Nanda R. Effect of low-frequency mechanical vibration on orthodontic tooth movement. Am J Orthod Dentofac Orthop. 2015;148:440–9.

    Article  Google Scholar 

  39. Song F, Eastwood AJ, Gilbody S, Duley L, Sutton AJ. Publication and related biases. Health Technol Assess. 2000;4:1–115.

    Google Scholar 

Download references


Not applicable.


This work was supported by the National Nature Science Foundation of China (Nos.31470904 and 11372202).

Availability of data and materials

The summary of data extraction in this study is available upon request to the corresponding author.

Author information

Authors and Affiliations



Literature search, study inclusion, data extraction and risk assessment: JD, XJ. Drafting manuscript: JD. Revising manuscript content: LY, LX, ZZ. Approving final version of manuscript: JD, XJ, LY, LX and ZZ.

Corresponding author

Correspondence to Zhihe Zhao.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jing, D., Xiao, J., Li, X. et al. The effectiveness of vibrational stimulus to accelerate orthodontic tooth movement: a systematic review. BMC Oral Health 17, 143 (2017).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: